The River Walk, or Paseo del Rio as it's known in Spanish, is the city's central entertainment district. It is home to several nightclubs, pubs, bars and restaurants. Among them are the Original Mexican Restaurant,Hard Rock Cafe, Boudro's, Pesca, Las Canarias, V Bar, Biga on the Banks, Jim Cullum's Landing, On The Half Shell Oyster Bar, Durty Nelly's, Mad Dogs on the River Walk, Casa Rio, County Line BBQ, Howl at the Moon, Rainforest Cafe, The Little Rhein Steak House, Fig Tree Restaurant and Dick's Last Resort.
Also in Downtown, the street scene includes several lounges, restaurants and bars. Among them The Palm, Mi Tierra Cafe Y Panaderia, Coyote Ugly, The Bonham Exchange, Rivercenter Comedy Club, Schilo's Deli, Zinc Wine and Champagne Bar, Steers and Beers Saloon, Morton's, The Steakhouse, Swig Martini Bar, Zen Bar, Suede Lounge, Drink, Club Rive, Tequila Del Rey, and The Basement.

The Strip (north of downtown) houses a concentration of bars catering to the LGBT community. Located on Main Street near San Antonio College, bars in the area include Sparky's Pub, The Saint, The Silver Dollar Saloon, Pegasus, and HEAT.
Another area popular with college students is the Saint Mary's Strip. In this area, several bars and restaurants can be found such as Paparay's, Joey's, The Mix, White Rabbit, Hardbodies, Demo's Greek Food, La Bikina, Jac's Lounge, Tycoon Flats, San Antonio Home Brew Supply & Bar, Limelight, and The Candlelight Cafe. The area is also home to the Josephine Theater, which since 1995 has been home to the Josephine Theatrical Company, a non-profit resident theater group. The theater originally opened in 1947 as an art-deco style neighborhood movie house.
San Antonio's largest university, The University of Texas at San Antonio (UTSA), is located on the northwest side of the city. Fox and Hound English Pub & Grille, The Flying Saucer, Hills & Dales Icehouse, Rome's Pizza, Chester's Hamburgers, and PF Changs are popular places on the northwest side.
There are several restaurants open 24 hours a day in San Antonio. Chachos, Mama Margies, Las Palapas, Whataburger, Jim's, The Original Mexican Restaurant, and Taco Cabana are all busy late-night establishments.
On the first Friday of every month, the area south of downtown known as Southtown or the King William District hosts an art walk known as First Friday. A diverse crowd of art lovers can visit galleries, art spaces, vintage stores, and street vendors selling art and jewelry, all while listening to live music played in the streets. Restaurants and bars in Southtown include Bar America, Blue Star Brewing Company (adjacent to Blue Star Contemporary Art Center), Rosario's, La Tuna, El Mirador, and Mad Hatters. Art spaces and galleries include Blue Star Contemporary Art Center, UTSA Satellite Space, San Antonio Art League, SAY Si!, Joan Grona Gallery, Cactus Bra Space, Three Walls Gallery, Justice Works, REM Gallery, San Angel Folk Art, Stone Metal Press, and Fiber Artspace. Events vary month to month and it's all free.
Second Saturday is usually on the following weekend after First Friday but sometimes falls on the very next day. Second Saturday is a monthly showcase of the area commonly known as SoFlo (a trendy abbreviation for the South Flores street where it is located) also known as the Lone Star District (named after the cross-street LoneStar Blvd. where the Lone Star Brewing Company once stood.) The area is only a few blocks South of the Blue Star District but is popular for those who want a less crowded environment than the one found at First Friday. Art galleries include One9Zero6, FL!GHT, LoneStar Studios, Salon Mijangos, Gallista Gallery, and Triangle Project Space. Artists in the area with studios include Andy Benavides, Justin Parr, Ed Saavedra, Zane Lewis, Thomas Cummins, and Dario Robleto. Once a year in the Fall, the S.M.A.R.T fair is an annual festival held to support the various arts in San Antonio